Charalampos (Harris) A. Lazaris, MS, Ph.D.
Bioinformatics Scientist (Research) - Whitehead Institute for Biomedical Research
I am a molecular biologist/bioinformatician with a particular interest in mechanisms of transcriptional dysregulation in cancer
EXPERIENCE
Bioinformatics Scientist (Research)
Young Laboratory
January 2020 - today
University of Southern California
Postdoctoral Scholar
January 2018 - today
Precision Oncology
New York University
PhD Candidate
August 2013 – January 2018
I worked on the 3D structure of human genome and its function in normal cells and leukemia.
University of California - San Diego
Staff Research Associate I
January 2013 – July 2013
As a member of the San Diego Center for Systems Biology, the Rifkin Laboratory investigates the origin of genetic, environmental and stochastic variation in biological systems and how it relates to phenotypic variability.
For more information on our work: Rifkin Lab
San Diego Center for Systems BiologyUniversity of Edinburgh
MSc in Bioinformatics
September 2011 – November 2012
During my thesis I developed EvoHeatmap, a program based on Basic Local Alignment Search Tool (BLAST) and Reciprocal Smallest Distance Algorithm, that can be used for the detection of putative protein orthologs in fungi.
University of Crete-Institute of Molecular Biology and Biotechnology
MSc in Molecular Biology-Biomedicine
Oct ober2006 – February2009
During my masters thesis, I performed single-cell level analysis of the expression of heat-shock proteins in yeast, investigating potential existence of transcriptional memory in the heat-shock response pathway.
University of Patras
Medical School
Sep 2005 – May 2006
Voluntary work on the role of Ets2 in the regulation of IL-2 transcription.
University of Pennsylvania
Undergraduate thesis
Mar 2005 – Aug 2005
Undergraduate thesis-Gene expression in ovarian cancer
EDUCATION
New York University
Research Doctorate in Computational and Systems Biomedicine (2013 - 2018)
New York University
Master of Science in Computational and Systems Biomedicine (2013 - 2016)
The University of Edinburgh
Master of Science (MSc) in Bioinformatics (2011 - 2012)
Awarded with Distinction
University of Crete
Master of Science in Molecular Biology (2006 - 2009)
Excellent - Grade: 8.68/10.00
University of Ioannina
BSc in Biological Applications & Technologies (2000 - 2005)
Excellent - Grade 8.94/10.00 (Ranked 1st)
SKILLS
Molecular Biology
Bioinformatics
Systems Biology
Cancer research
PUBLICATIONS
Henninger JE, Oksuz O, Shrinivas K, Sagi I, LeRoy G, Zheng MM, Andrews JO, Zamudio AV, Lazaris C, Hannett NM, Lee TI, Sharp PA, Cissé II, Chakraborty AK, Young RA. RNA-Mediated Feedback Control of Transcriptional Condensates. Cell. 2020 Dec 9:S0092-8674(20)31567-1. doi: 10.1016/j.cell.2020.11.030. Epub ahead of print. PMID: 33333019.
Geiler-Samerotte KA, Li S, Lazaris C, et al. Extent and context dependence of pleiotropy revealed by high-throughput single-cell phenotyping [published online ahead of print, 2020 Aug 17]. PLoS Biol. 2020;18(8):e3000836.doi:10.1371/journal.pbio.3000836
Kloetgen A, Thandapani P, Ntziachristos P, Ghebrechristos Y, Nomikou S, Lazaris C, Chen X, Hu H, Bakogianni S, Wang J, Fu Y, Boccalatte F, Zhong H, Paietta E, Trimarchi T, Zhu Y, Van Vlierberghe P, Inghirami GG, Lionnet T, Aifantis I, Tsirigos A. Three-dimensional chromatin landscapes in T cell acute lymphoblastic leukemia. Nat Genet. 2020 Apr;52(4):388-400. doi:10.1038/s41588-020-0602-9. Epub 2020 Mar 23. PubMed PMID: 32203470; PubMed Central PMCID: PMC7138649.
Lazaris C*, Aifantis I, Tsirigos A. On Epigenetic Plasticity and Genome Topology. Trends Cancer. 2020 Mar;6(3):177-180. doi:
10.1016/j.trecan.2020.01.006. Epub 2020 Feb 7. PubMed PMID: 32101721.*Corresponding author
Kourtis N*, Lazaris C*, Hockemeyer K, Balandrán JC, Jimenez AR, Mullenders J, Gong Y, Trimarchi T, Bhatt K, Hu H, Shrestha L, Ambesi-Impiombato A, Kelliher M, Paietta E, Chiosis G, Guzman ML, Ferrando AA, Tsirigos A, Aifantis I. Oncogenic hijacking of the stress response machinery in T cell acute lymphoblastic leukemia. Nat Med. 2018 Aug; 24(8) 1157-1116. doi: 10.1038/s41591-018-0105-8. Epub 2018 Jul 23.
*Equal contribution
Yixiao Gong*, Charalampos Lazaris*, Theodore Sakellaropoulos, Aurelie Lozano, Prabhanjan Kambadur, Panagiotis Ntziachristos, Iannis Aifantis & Aristotelis Tsirigos. Stratification of TAD boundaries reveals preferential insulation of super-enhancers by strong boundaries. Nature Communications 9 (542), doi:10.1038/s41467-018-03017-1 (Feb 7th 2018).
*Equal contribution
Fanok MH, Sun A, Fogli LK, Narendran V, Eckstein M, Kannan K, Dolgalev I, Lazaris C, Heguy A, Laird ME, Sundrud MS, Liu C, Kutok J, Lacruz RS, Latkowski JA, Aifantis I, Ødum N, Hymes KB, Goel S, Koralov SB. Role of dysregulated cytokine signaling and bacterial triggers in the pathogenesis of Cutaneous T Cell Lymphoma. J Invest Dermatol. 2017 Nov 8. pii: S0022-202X(17)33144-5. doi: 10.1016/j.jid.2017.10.028. [Epub ahead of print]
Modrek AS, Golub D, Khan T, Bready D, Prado J, Bowman C, Deng J, Zhang G, Rocha PP, Raviram R, Lazaris C, Stafford JM, LeRoy G, Kader M, Dhaliwal J, Bayin NS, Frenster JD, Serrano J, Chiriboga L, Baitalmal R, Nanjangud G, Chi AS, Golfinos JG, Wang J, Karajannis MA, Bonneau RA, Reinberg D, Tsirigos A, Zagzag D, Snuderl M, Skok JA, Neubert TA, Placantonakis DG. Low-Grade Astrocytoma Mutations in IDH1, P53, and ATRX Cooperate to Block Differentiation of Human Neural Stem Cells via Repression of SOX2. Cell Reports 2017 Oct; 21(5) 1267-1280
Strikoudis A, Lazaris C, Ntziachristos P, Tsirigos A and Aifantis I. Opposing functions of H2BK120 ubiquitylation and H3K79 methylation in the regulation of pluripotency by the Paf1 complex. Cell Cycle 2017. DOI: 10.1080/15384101.2017.1295194
Charalampos Lazaris, Stephen Kelly,
Panagiotis Ntziachristos, Iannis Aifantis & Aristotelis Tsirigos. HiC-bench: comprehensive and reproducible Hi-C data analysis designed for parameter exploration and benchmarking. BMC Genomics 2017 18:22. doi: 10.1186/s12864-016-3387-6
Strikoudis A, Lazaris C, Trimarchi T, Galvao Neto AL, Yang Y, Ntziachristos P, Rothbart S, Buckley S, Dolgalev I, Stadtfeld M, Strahl BD, Dynlacht BD, Tsirigos A, Aifantis I. Regulation of transcriptional elongation in pluripotency and cell differentiation by the PHD-finger protein Phf5a. Nat Cell Biol. 2016 Nov;18(11):1127-1138. doi: 10.1038/ncb3424.
King B, Boccalatte F, Moran-Crusio K, Wolf E, Wang J, Kayembe C, Lazaris C, Yu X, Aranda-Orgilles B, Lasorella A, Aifantis I. The ubiquitin ligase Huwe1 regulates the maintenance and lymphoid commitment of hematopoietic stem cells. Nat Immunol. 2016 Nov;17(11):1312-1321. doi: 10.1038/ni.3559.
N. Kourtis, R. S. Moubarak, B. Aranda-Orgilles, K. Lui, I. T. Aydin, T. Trimarchi, F. Darvishian, C. Salvaggio, J. Zhong, K. Bhatt, E. I. Chen, J. T. Celebi, C. Lazaris, A. Tsirigos, I. Osman, E. Hernando, and I. Aifantis. FBXW7 modulates cellular stress response and metastatic potential through HSF1 post-translational modification. Nat Cell Biol, vol. 17, no. 3, pp. 322–332.
LOCATION
Whitehead Institute for Biomedical Research
455 Main Street
Cambridge, MA 02142
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